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Evidence to support the idea that prednisone causes increased fat storage and muscle loss is derived from a study by Al-Jaouni et al. [21] who showed that individuals with severe diabetes and prednisone-resistant diabetes (i.e. who would require treatment with prednisone to control their glucose levels) had greater fat accumulation and lower muscle mass (compared with people with prednisone-sensitive diabetes). Similarly, a study of 13 patients with severe diabetes who were treated with prednisone found that the patients with prednisone-sensitive diabetes had greater postural fat deposits, lower muscle mass (compared with people who developed prednisone-resistant diabetes) and lower levels of the amino acid Leucine than patients with prednisone-sensitive diabetes [12]. In patients with prednisone-resistant diabetes who are not taking oral medications, the increased fat reserves could be due in some part to their reduced body fat content. However, the relationship between fat storage and muscle loss in people with prednisone resistance cannot be entirely explained by muscle-reducing drugs. Several small, short term studies have shown that prednisone increases fat storage in humans and animals both with and without body-fat gain [22–24]. Interestingly, most investigators who analyzed human and animal data concluded that hypoglycemia reduces fat storage but can also lead to greater fat loss. However, if these results are extrapolated to obese humans, then prednisone could be a poor fat-loss agent. This conclusion is supported by the results of a study of 16 prednisone-sensitive patients who were followed over 36 weeks in a low carbohydrate diet [28], where weight loss did not occur, even in patients taking prednisone to lower their blood glucose. However, the investigators did note that patients with hypoglycemic symptoms who developed prednisone resistance did not experience significant weight loss [28]. In contrast, when the investigators followed people with prednisone resistance for 17 weeks, with or without body fat levels in the range of 27% [13], their results were similar to patients who did not develop prednisone resistant diabetes. Some data suggest that hypoglycemia has no effect on human body fat [23], while others show that, in humans, hypoglycemia can alter the balance of various amino acids (e.g. L-Carnitine in fish) and the amino acid balance of different body fat depots [18, 30]. Interestingly, these data suggest that a hypoglycemic state leads to a decrease in muscle mass and an increase in muscle lipid storage in humans [18]. Concluding Remarks As has Similar articles:

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Where to buy legal steroids in canada, steroids for sale

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